Gene Silencing CUTs Both Ways

Gene Silencing CUTs Both Ways

There is extensive transcription throughout the eukaryotic genome resulting in both antisense transcripts from coding regions and cryptic unstable transcripts (CUTs) from intergenic regions. In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deac...

IKK cuts both ways in Huntington's disease

Opposing motors take the strain M olecular motors show an odd sense of teamwork during cargo transport, say Ally et al. In order to get somewhere, they have to pull in opposite directions. Many types of cargo move through the cell along micro-tubules, but rather than smoothly gliding to their fi nal destinations, they stutter back and forth due to motor proteins that pull in opposite directions...

C. elegans Aging: Proteolysis Cuts Both Ways

Recent reports from two laboratories working on the nematode Caenorhabditis elegans have identified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of longevity by the insulin/insulin-like growth factor signaling pathway.

Tomato and Tobacco Phytoene Desaturase Gene Silencing by Virus-Induced Gene Silencing (VIGS) Technique

Background and Aims: Virus-Induced Gene Silencing (VIGS) is a virus vector technology that exploits antiviral defense mechanism. By infecting plants with recombinant viruses containing host genes inserted in the viral genome, VIGS achieves the RNA silencing process. The purpose of this study was to investigate the possibility of tomato (Lycopersicon esculentum Mill.) and tobacco (Nicotiana be...

Barcan Both Ways